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Abbreviations : BC Breast cancer, BCNS Basal cell nevus syndrome, CRC Colorectal cancer, DCR Disease control rate, HCC Hepatocellular carcinoma, HNC Head and neck cancer, laBCC Locally advanced basal cell carcinoma, mBCC Metastatic basal cell carcinoma, MPM Malignant pleural mesothelioma, NC NUT midline carcinoma NSCLC, non-small Cell Lung Cancer, ORR Objective response rate, OS Overall survival, PAC Pancreatic cancer, PDAC Pancreatic ductal adenocarcinoma, PFS Progression-free survival, PM Peritoneal metastases, SCLC Small cell lung cancer Conclusion and future perspectives The relationship between tumors and TME is like fish and water, in which TME greatly facilitates the proliferation and progression of tumors